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Simparica Chewables for Dogs – Powerful Flea & Tick Treatment

Fleas and ticks can make life uncomfortable for your dog and quickly turn a small problem into a full-blown infestation. Simparica Chewables for Dogs offer a convenient monthly treatment that kills adult fleas and controls six species of ticks, helping protect your dog against common external parasites.

Powered by sarolaner, an active ingredient from the isoxazoline class, Simparica works through your dog’s bloodstream to target fleas and ticks when they feed. Its flavored chewable formula makes monthly administration simple, whether offered by hand or with food. With six weight-based strengths, you can find an appropriate option for dogs weighing from 2.8 to 132 lbs.

Benefits and Advice for Pet Parents

Powerful Flea Control: Kills adult fleas and helps treat and prevent flea infestations.
Six Tick Species: Treats and controls Lone Star, Gulf Coast, American dog, black-legged (deer), brown dog, and Asian longhorned ticks.
Fast-Acting Formula: Laboratory studies show Simparica begins killing fleas within 3 hours of administration.
Helps Prevent Lyme Disease: Indicated for preventing Borrelia burgdorferi infections as a direct result of killing black-legged ticks that transmit the bacteria.
Convenient Monthly Chew: One flavored chewable tablet provides a simple monthly treatment.
Easy Administration: Can be offered directly by hand, mixed with food, or administered like other tablets.
Multiple Strengths: Available in six strengths to accommodate dogs of different weights.
Year-Round Flea Control: Monthly treatment can continue throughout the year in areas where fleas are common year-round.

Active Ingredient:

Sarolaner

Important: Simparica is a prescription animal drug in the United States. It is intended for dogs at least 6 months old and weighing 2.8 lbs or more. It is not a heartworm or intestinal worm treatment.

How to Use Simparica Chewables

Simparica is an oral chewable tablet administered once a month. Follow these instructions to ensure your dog receives the complete dose.

Check Your Dog’s Weight: Weigh your dog and select the appropriate Simparica strength from the dosage chart below.
Choose the Administration Method: Offer the chewable directly by hand, mix it with food, or administer it like another tablet medication.
Ensure Complete Consumption: Watch your dog for a few minutes after administration to confirm the entire dose has been swallowed.
Maintain Monthly Treatment: Administer one dose every month to maintain ongoing flea and tick control.
Follow the Missed-Dose Instructions: If you miss a dose, administer Simparica when you remember and resume the monthly dosing schedule.

Important Administration Guidelines:

Simparica can be started at any time of the year.
In areas with year-round flea activity, continue monthly treatment without interruption.
Treat all dogs and cats in the household with an appropriate, approved flea-control product to help reduce reinfestation.
Do not split or divide the chewable tablet.
Always follow your veterinarian’s instructions and the product label.

Safety & Storage Information

Before administering Simparica, review these precautions to help protect your dog and ensure responsible use.

Safety Precautions:

Dogs Only: Simparica is formulated exclusively for dogs. Never administer it to cats or other animal species.
Age Requirement: Do not use Simparica in dogs younger than 6 months.
Minimum Weight: Only use in dogs weighing 2.8 lbs or more.
Neurological Precautions: Sarolaner belongs to the isoxazoline class, which has been associated with neurological reactions, including tremors, ataxia, and seizures.
History of Seizures: Use caution in dogs with a history of seizures or neurological disorders. Discuss your dog’s medical history with a veterinarian before treatment.
Pregnancy and Nursing: The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs. Consult your veterinarian before use.
Possible Side Effects: Vomiting, diarrhea, lethargy, and reduced appetite have been reported. Contact your veterinarian if you notice unusual symptoms.
Prescription Requirement: US federal law restricts Simparica to use by or on the order of a licensed veterinarian.
Accidental Ingestion: Keep the medication away from children and other animals. Contact a physician immediately if a person accidentally ingests the product.

Storage Instructions:

Store Simparica at or below 86°F (30°C).
Temperature excursions up to 104°F (40°C) are permitted.
Keep the medication in its original packaging until needed.
Store in a secure location out of reach of children, dogs, cats, and other animals to prevent accidental ingestion or overdose.

Simparica Dosage Chart for Dogs

Simparica Chewables are available in six strengths. Select the appropriate tablet according to your dog’s current body weight.

Dog Weight	Dog Size	Pack Color	Sarolaner Strength	Chews Per Month
2.8–5.5 lbs	Puppies / Extra Small Dogs	Yellow	5 mg	One
5.6–11 lbs	Extra Small Dogs	Purple	10 mg	One
11.1–22 lbs	Small Dogs	Caramel	20 mg	One
22.1–44 lbs	Medium Dogs	Blue	40 mg	One
44.1–88 lbs	Large Dogs	Green	80 mg	One
88.1–132 lbs	Extra Large Dogs	Brown	120 mg	One

Important: For dogs weighing more than 132 lbs, use the appropriate combination of Simparica tablets as directed by your veterinarian. Each treatment should provide the recommended minimum dosage of 2 mg/kg (0.91 mg/lb).

Frequently Asked Questions About Simparica Chewables for Dogs

1. What Is Simparica for Dogs?

Simparica is a flavored monthly chewable flea and tick treatment for dogs. It contains sarolaner, an active ingredient that kills adult fleas and treats and controls six tick species. It is also indicated for preventing Borrelia burgdorferi infections resulting from killing black-legged ticks.

2. How Does Simparica Work?

Simparica contains sarolaner, an insecticide and acaricide belonging to the isoxazoline class. After administration, sarolaner is absorbed into your dog’s bloodstream. When fleas and ticks feed, they are exposed to the active ingredient, which interferes with their nervous system by affecting GABA and glutamate receptors, leading to uncontrolled neuromuscular activity and parasite death.

3. How Often Should I Give Simparica to My Dog?

Simparica should be administered once every month at the recommended dosage. Maintaining the monthly schedule helps provide ongoing flea and tick control.

4. How Quickly Does Simparica Kill Fleas and Ticks?

Simparica begins killing fleas within 3 hours of administration. Laboratory studies demonstrated at least 96.2% reduction in live fleas within 8 hours after infestation. It also demonstrated at least 99% effectiveness against initial infestations of the six labeled tick species within 48 hours.

5. What Types of Ticks Does Simparica Kill?

Simparica treats and controls six tick species:

Gulf Coast ticks (Amblyomma maculatum).
Asian longhorned ticks (Haemaphysalis longicornis).
American dog ticks (Dermacentor variabilis).
Black-legged (deer) ticks (Ixodes scapularis).
Lone Star ticks (Amblyomma americanum).
Brown dog ticks (Rhipicephalus sanguineus).

6. Does Simparica Help Prevent Lyme Disease?

Yes. Simparica is indicated for preventing Borrelia burgdorferi infections as a direct result of killing black-legged ticks that carry the bacteria. It is important to understand that this indication does not mean Simparica prevents every tick-borne disease.

7. At What Age Can Puppies Start Taking Simparica?

Simparica is approved for dogs 6 months of age and older. Puppies must also weigh at least 2.8 lbs before starting treatment. It should not be administered to younger puppies.

8. Is Simparica Safe for All Dog Breeds?

Simparica is intended for dogs meeting its age and weight requirements. However, individual health conditions and medical history matter. Dogs with a history of seizures or neurological disorders require particular caution because sarolaner belongs to the isoxazoline class.

9. Can Simparica Be Given to Pregnant or Nursing Dogs?

The safety of Simparica has not been evaluated in breeding, pregnant, or lactating dogs. Consult your veterinarian before administering it to dogs in these conditions.

10. What Is the Difference Between Simparica and Simparica Trio?

Both products contain sarolaner, but they offer different parasite coverage.

Simparica: Contains sarolaner and targets adult fleas and six tick species.

Simparica Trio: Combines sarolaner, moxidectin, and pyrantel. It provides flea and tick treatment along with heartworm prevention and treatment and control of certain intestinal worms.

Choose the appropriate product based on your dog’s parasite-control needs and veterinary recommendation.

11. Can Simparica Be Given With Other Medications?

Simparica has been used alongside commonly administered veterinary treatments in clinical studies. However, always consult your veterinarian before combining it with other medications or parasite preventives, particularly if your dog has an existing health condition.

12. What Happens If I Miss a Dose of Simparica?

If you miss a dose, administer Simparica as soon as you remember and resume the regular monthly dosing schedule. Keeping track of monthly treatment dates can help avoid gaps in parasite protection.

13. Can I Give Simparica With Food?

Yes. Simparica can be offered directly by hand, mixed with food, or administered like other tablet medications. Make sure your dog consumes the complete dose.

14. What Strengths Are Available for Simparica Chewables?

Simparica comes in six strengths based on your dog’s body weight:

5 mg for dogs weighing 2.8–5.5 lbs.
10 mg for dogs weighing 5.6–11 lbs.
20 mg for dogs weighing 11.1–22 lbs.
40 mg for dogs weighing 22.1–44 lbs.
80 mg for dogs weighing 44.1–88 lbs.
120 mg for dogs weighing 88.1–132 lbs.

Each tablet provides one monthly dose for the corresponding weight range.

15. Does Simparica Protect Dogs Against Heartworms and Intestinal Worms?

No. Simparica contains sarolaner only and is designed for flea and tick control. It does not prevent heartworm disease or treat intestinal worms. If your dog needs broader parasite protection, discuss options such as Simparica Trio with your veterinarian.