Frontline Plus for Small Dogs – Orange

Packs

3 Pipettes6 Pipettes12 Pipettes

Clear

Frontline Plus for Medium Dogs – Blue

Packs

3 Pipettes6 Pipettes12 Pipettes

Clear

Frontline Plus for Large Dogs – Purple

Packs

3 Pipettes6 Pipettes12 Pipettes

Clear

Frontline Plus for Extra Large Dogs – Red

Packs

3 Pipettes6 Pipettes12 Pipettes

Clear

Frontline Plus Flea & Tick Treatment for Dogs

Fleas and ticks can quickly become an uncomfortable problem for your dog, especially when they continue multiplying around your home. Frontline Plus for Dogs offers a convenient monthly spot-on treatment that kills adult fleas, flea eggs, and larvae while treating and controlling tick and chewing lice infestations.

Powered by two active ingredients, fipronil and (S)-methoprene, Frontline Plus targets different stages of the flea life cycle. Its waterproof topical formula spreads across your dog’s skin and coat, helping maintain parasite control even after bathing or water exposure. With four weight-specific applicator sizes, finding the right treatment for your dog is straightforward.

Benefits and Advice for Pet Parents

Dual-Action Formula: Combines 9.8% fipronil and 8.8% (S)-methoprene to target adult fleas and interrupt the flea life cycle.
Complete Flea Life-Cycle Control: Kills adult fleas, flea eggs, and larvae while preventing immature flea stages from developing.
Protection Against Four Tick Species: Kills brown dog, American dog, Lone Star, and black-legged (deer) ticks, including their larval, nymph, and adult stages.
Chewing Lice Control: Rapidly eliminates chewing lice infestations.
Sarcoptic Mange Support: Aids in controlling sarcoptic mange infestations.
Waterproof Formula: Continues working after bathing, water immersion, and exposure to sunlight.
Convenient Monthly Application: One topical applicator provides a simple monthly treatment routine.
Suitable for Puppies: Labeled for puppies 8 weeks of age and older, subject to the minimum weight requirement for the selected size.
Pregnancy and Nursing: Approved for use in breeding, pregnant, and lactating dogs when applied as directed.
Four Weight-Based Sizes: Available in applicators for small, medium, large, and extra-large dogs.

Active Ingredients:

Fipronil – 9.8%
(S)-methoprene – 8.8%

How to apply FRONTLINE®

Frontline Plus is a topical spot-on treatment that must be applied directly to your dog’s skin. Follow these steps for proper application:

Step 1: Remove the Applicator

Separate one blister from the package using scissors. Cut along the dotted line and peel away the foil to remove the applicator.

Step 2: Open the Applicator

Hold the applicator upright with the foil side facing you. Snap off the applicator tip to open it.

Step 3: Apply Frontline Plus

Part your dog’s hair between the shoulder blades until the skin is visible. Place the applicator tip just above the skin and squeeze out the entire contents in one spot. Apply directly to the skin, not on top of the hair coat.

Important Application Instructions:

Use the complete applicator appropriate for your dog’s weight.
Apply one treatment per dog every 30 days.
Do not use more than one application per dog per month.
Avoid touching the treated area until it is completely dry.
Do not allow your dog to lick or ingest the product.
Keep cats away from treated dogs for 24 hours or until the application site has dried.
Follow the product label instructions for bathing and grooming after application.

Safety & Storage Information

Before using Frontline Plus, review these important precautions to help ensure safe application.

Safety Precautions:

For Dogs Only: Never use Frontline Plus for Dogs on cats, rabbits, or other animals. The dog formulation can be harmful if applied to cats.
Age and Weight Requirements: Use only on dogs and puppies 8 weeks of age and older, meeting the minimum weight requirement for their selected applicator size.
External Use Only: Apply directly to your dog’s skin. Do not allow your dog to swallow the product.
Avoid Contact Until Dry: Keep children and other pets away from the treated area until the application site is completely dry.
Pregnant and Nursing Dogs: Frontline Plus is approved for breeding, pregnant, and lactating dogs when used as directed.
Sensitive Dogs: Temporary irritation at the application site may occur. If irritation persists or becomes more severe, contact your veterinarian.
Medicated or Unwell Dogs: Consult your veterinarian before treating aged, medicated, debilitated, or unwell dogs.
Safe Handling: Wash your hands thoroughly with soap and water after handling the applicator. Avoid contact with your eyes, skin, and clothing.
Accidental Ingestion: If the product is swallowed, contact a poison control center or doctor immediately for treatment advice. If it gets into the eyes, rinse gently with water for 15–20 minutes and seek medical advice.

Storage Instructions:

Keep unused applicators in their original packaging and store them out of reach of children and animals.
Do not contaminate food, water, or animal feed during storage or disposal.
Do not store or use the product near heat or an open flame, as it is combustible.
Dispose of unused product according to the label and local disposal requirements.

Follow Frontline Plus dosage chart for dog given below for appropriate pack size

Choose the appropriate Frontline Plus applicator according to your dog’s current body weight. Each applicator contains one monthly treatment.

Dog Size	Dog Weight	Pack Color	Applicator Volume	Active Ingredients
Small Dogs	5–22 lbs	Orange	0.67 ml	9.8% Fipronil + 8.8% (S)-methoprene
Medium Dogs	23–44 lbs	Blue	1.34 ml	9.8% Fipronil + 8.8% (S)-methoprene
Large Dogs	45–88 lbs	Purple	2.68 ml	9.8% Fipronil + 8.8% (S)-methoprene
Extra Large Dogs	89–132 lbs	Red	4.02 ml	9.8% Fipronil + 8.8% (S)-methoprene

Important: For dogs weighing over 132 lbs, consult your veterinarian for an appropriate treatment recommendation. Do not use two applicators.

Frequently Asked Questions (FAQs)

1. What Is Frontline Plus for Dogs?

Frontline Plus is a waterproof topical flea and tick treatment containing fipronil and (S)-methoprene. It kills adult fleas, flea eggs, and larvae while treating and controlling ticks and chewing lice. It also aids in the control of sarcoptic mange infestations.

2. How Often Should I Apply Frontline Plus to My Dog?

Frontline Plus should be applied once every 30 days for ongoing flea, tick, and chewing lice control. Regular monthly application helps break the flea life cycle and maintain continuous parasite control.

3. How Does Frontline Plus Work on Dogs?

Frontline Plus combines two active ingredients. Fipronil targets adult fleas, ticks, and chewing lice by disrupting their nervous systems, while (S)-methoprene prevents immature flea stages from developing. After application, the formula spreads across your dog’s skin and coat.

4. Does Frontline Plus Kill Flea Eggs and Larvae?

Yes. Frontline Plus kills flea eggs and larvae and prevents immature flea stages from developing into adult fleas. This dual-action approach helps interrupt the flea life cycle and reduce the risk of recurring infestations.

5. What Types of Ticks Does Frontline Plus Kill?

Frontline Plus kills all life stages of four tick species: brown dog ticks, American dog ticks, Lone Star ticks, and black-legged (deer) ticks. These ticks may transmit Lyme disease and other tick-borne illnesses.

6. Can Frontline Plus Help Control Sarcoptic Mange?

Yes. Frontline Plus aids in the control of sarcoptic mange infestations. However, multiple monthly treatments may be required for mite elimination. Consult your veterinarian for an appropriate diagnosis and treatment plan.

7. Is Frontline Plus Waterproof?

Yes. Frontline Plus remains effective after bathing, water immersion, and exposure to sunlight. However, follow the application instructions and allow the treated area to dry completely before allowing contact with children or other pets.

8. At What Age Can Puppies Use Frontline Plus?

Frontline Plus can be used on puppies from 8 weeks of age, provided they meet the minimum weight requirement for the selected applicator. The smallest size is intended for dogs weighing 5–22 lbs.

9. Is Frontline Plus Safe for Pregnant or Nursing Dogs?

Yes. According to the US product label, Frontline Plus is approved for use in breeding, pregnant, and lactating dogs when applied as directed. Consult your veterinarian if your dog has additional health concerns.

10. Can I Use Frontline Plus on My Cat?

No. Frontline Plus for Dogs is specifically formulated for dogs and must never be applied to cats. Keep cats away from treated dogs for 24 hours or until the application site is completely dry.

11. What Should I Do If I Still See Fleas After Applying Frontline Plus?

Seeing fleas after treatment does not necessarily mean the product has failed. Newly emerged fleas from the surrounding environment may continue to appear and come into contact with your treated dog. Continue the recommended monthly treatment schedule and address flea sources in your home and environment.

12. Can I Use Frontline Plus With Other Flea and Tick Treatments?

Do not combine Frontline Plus with other flea and tick treatments without veterinary guidance. Using multiple parasite-control products together may result in unnecessary exposure to active ingredients. Ask your veterinarian before combining treatments.

13. Does Frontline Plus Prevent Lyme Disease?

Frontline Plus kills black-legged ticks that may transmit Lyme disease. However, it is not a Lyme disease vaccine and does not guarantee that your dog will avoid infection. Ask your veterinarian about additional Lyme disease prevention measures.