Simparica TRIO for Dogs

Simparica Trio for Dogs (Yellow)

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Simparica Trio for Dogs (Purple)

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Simparica Trio for Dogs (Caramel)

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3 Pack6 Pack

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Simparica Trio for Dogs (Teal)

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Simparica Trio for Dogs (Green)

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Simparica Trio – Broad-Spectrum Treatment for Dogs

Are you concerned about your dog’s protection from fleas, ticks, heartworms, and intestinal worms? Simparica Trio for Dogs is the solution you have been searching for. According to Zoetis USA, it is the #1 vet-prescribed combination preventive, offering comprehensive protection against both internal and external parasites. This flea, tick & worm treatment for dogs comes in a delicious, pork liver-flavored, chewable form that dogs love. Additionally, it can be administered with or without food, offering flexible administration options.

Simparica Trio, an all-in-one treatment for dogs, is the first product to combine a trio of active ingredients (sarolaner, moxidectin, and pyrantel) in one chew. It is the only combination dog formula proven to kill 6 species of ticks, ensuring your dog stays tick-safe throughout the year. Just one Simparica Trio tasty chew a month protects your furry friend against all common parasites. It’s simple, effective, and reliable!

Recommended For:

Puppies & dogs.
Simparica Trio is recommended for puppies and dogs from 8 weeks of age and weighing at least 2.8 lbs.

Simparica Trio Coverage:

Prevents heartworm disease caused by Dirofilaria immitis.
Treats & controls roundworm and hookworm infections.
Kills adult fleas before they can lay eggs.
Treats and prevents flea infestations.
Improves signs of flea allergy dermatitis.
Prevents flea and tapeworm (Dipylidium caninum) infections.
Treats & controls tick infestations (lone star tick, Gulf Coast tick, American dog tick, black-legged tick, brown dog tick, and Asian longhorned tick).
Indicated for the prevention of Lyme disease (Borrelia burgdorferi) infections as a result of killing black-legged vector ticks.

Directions

Administer Simparica Trio Chew orally as a single dose at monthly intervals or as directed by your veterinarian.
It can be administered with or without food.
After treatment, observe the dog for some time to ensure the dog consumes the complete dose.
If you miss a dose, give one dose and resume the monthly dosing schedule.
For flea, tick and flea tapeworm protection, you can begin your dog’s treatment with Simparica Trio at any time of the year.
For heartworm prevention, administer it year-round. It should be administered at least within one month after the dog’s first exposure to mosquitoes and continuing until at least one month after the dog’s last seasonal exposure.
For continuous, year-round protection, continue treating your dog with Simparica Trio the entire year without interruption.

Why Should You Buy Simparica TRIO?

#1 Vet-prescribed combination preventive that lasts a month long without losing effectiveness.
Tasty pork liver-flavored chewable form allows fuss-free, easy administration.
The only dog parasite preventive that combines three active ingredients in one chew.
The first canine treatment to protect against six different tick species.
A single chew per month protects against both internal and external parasites.
Improves clinical signs of flea allergy dermatitis (FAD).
Indicated for the prevention of Lyme disease infections as a direct result of killing black-legged ticks.

How Does Simparica TRIO Work?

Simparica Trio contains sarolaner, moxidectin, and pyrantel as the active ingredients. After administration, the chew releases these active ingredients into the dog’s bloodstream. The formula is distributed to tissue fluids under the dog’s skin. As soon as parasites take the blood meal from the treated dog, they ingest the formula.

Sarolaner obstructs the neuromuscular activity, leading to death in insects. It treats and prevents flea infestations and treats and controls tick infestations. Moxidectin interferes with parasites’ neurotransmission, resulting in paralysis and death, thus providing protection from heartworm disease. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in exposed parasites. This causes paralysis and death or expulsion of the organisms, thus treating and controlling roundworms and hookworms.

Laboratory studies suggest that a single dose of Simparica Trio is 100% effective in preventing the development of heartworm disease. According to a lab study, the chews began killing fleas at four hours and started killing black-legged ticks within eight hours. It provided 100% flea efficacy at eight hours after administration and reduced the number of live ticks by more than 94% within 24 hours of infestation.

Simparica TRIO Dosing Guide:

Dog Weight	Pack Color	Sarolaner Strength (mg)	Moxidectin Strength (mg)	Pyrantel Strength (mg)	Doses Administered
2.8 – 5.5 lbs	Yellow	3	0.06	12.5	One
5.6 – 11.0 lbs	Purple	6	0.12	25.0	One
11.1 – 22.0 lbs	Caramel	12	0.24	50.0	One
22.1 – 44.0 lbs	Blue	24	0.48	100.0	One
44.1 – 88.0 lbs	Green	48	0.96	200.0	One
88.1 – 132.0 lbs	Brown	72	1.44	300.0	One
For dogs over 132.0 lbs, administer the appropriate combination of Simparica Trio chews

Safety

Simparica Trio Chew is for dogs only. This treatment is not for use in humans or any other animal species. You should keep these chews out of the reach of children, uninformed people, and pets. In case of accidental ingestion, immediately consult a physician.

Before administration, test your dogs for existing heartworm infections and treat infected dogs to remove adult heartworms at the vet’s recommendation. The safe use of Simparica Trio has not been evaluated in pregnant, breeding, or lactating dogs.

Sarolaner, one of the active ingredients in the treatment, belongs to the isoxazoline class. Use Simparica Trio with caution in dogs with a history of seizures or neurologic disorders. It should not be used in puppies and dogs under 8 weeks of age.

In field studies, Simpairca Trio was used with veterinary treatments, including vaccines, anthelmintics, antimicrobials, antiprotozoals, analgesics, NSAIDs, and anesthetic agents without any adverse reactions.

Storage Guide:

Store at or below 30°C (86°F).

Frequently Asked Questions (FAQs)

How is Simparica Trio different from other dog treatments?

Simparica Trio is the only oral dog treatment that protects against 6 tick species, heartworm disease, fleas and intestinal worms, all in one tasty chew per month. It is the first chew that combines three active ingredients for comprehensive protection.

At what age can I start treating my dog with Simparica Trio?

Simparica Trio is recommended for use in puppies from 8 weeks of age, weighing at least 2.8 lbs.

How do I switch to Simparica Trio from another flea, tick or heartworm treatment?

Before switching, talk to your veterinarian. Administer the first dose of Simparica Trio within one month of the last dose of the former preventive (only when you were using a monthly treatment previously). It is necessary to ensure your dog is kept protected through the process.

How does Simparica Trio protect from tapeworms?

Dogs usually get infected with tapeworms by swallowing fleas that carry developing tapeworms. Therefore, flea control is essential for preventing tapeworm infections. Simparica Trio prevents flea tapeworm (Dipylidium caninum) by killing fleas.

What happens if I miss a dose or my dog vomits after administration?

If you miss a dose, administer a new dose. In case your dog vomits shortly after dosing, give another chew. Consult a vet before redosing within one month.

Is Simparica Trio safe?

Simparica Trio is safe for use in puppies and dogs from 8 weeks of age and older and weighing 2.8 lbs or greater.

Can I split Simparica Trio chews for administration?

No. It is not advisable to score these chews and they should not be divided.

What is the primary difference between Simparica and Simparica Trio?

Simparica has only one active ingredient (sarolaner) and is effective against fleas and ticks. Simparica Trio has two more active ingredients, moxidectin and pyrantel, in addition to sarolaner. As a result, it protects dogs against fleas, ticks, heartworm disease, roundworms and hookworms. Both Simparica and Simparica Trio are indicated to prevent Lyme disease infections as a direct result of killing black-legged vector ticks.

Can I use Simparica Trio together with other heartworm, flea or tick treatments?

Simparica Trio is effective in protecting dogs against heartworm disease, fleas, ticks and intestinal worms. Therefore, there is no need to use another treatment with it for protection against these parasites.