Nexgard Plus Vs. Simparica Trio: Which Parasite Treatment Is Best for Your Dog in 2025?

Our dogs have to cope with a lot of parasites, like fleas, ticks, heartworms, and intestinal worms. If you don’t take these parasites seriously, you’re putting your dog friends in risk, which is not a good idea and not something a kind and caring dog parent would do. You need to give your four-legged pets a good antiparasitic therapy that keeps them safe from all of these blood-sucking bugs.

There are countless products on the market that can help dogs with fleas, ticks, and other parasites. But we’ve narrowed it down to two of the best treatments: Simparica Trio Vs. Nexgard Plus.

We will compare these two vet-recommended brands in this article so that you can choose the best therapy for your pet.

An Overview of Nexgard Plus Vs. Simparica Trio

Nexgard Plus is a pleasant, beef-flavored medicine that works on puppies and dogs that are 8 weeks old or older and weigh 4 pounds or more. One dosage of Nexgard Plus protects against fleas, ticks, heartworm disease, and intestinal worms like roundworms and hookworms for a month.

Simparica Trio is a tasty liver-flavored all-in-one medication for dogs and puppies 8 weeks and older that weigh at least 2.8 pounds. Dogs can avoid fleas, ticks, heartworm disease, and gastrointestinal worms like roundworms and hookworms by getting one dose of Simparica Trio every month.

Nexgard Plus and Simparica Trio: What They Have in Common?

There are several things that Nexgard Plus and Simparica Trio have in common. Here’s what they all have in common:

1. Minimum Age requirement

The age requirement for giving Nexgard Plus and Simparica Trio is the same. You can use either of these medicines on puppies who are at least 8 weeks old.

2. How to take it, what kind of treatment it is, and how long it lasts

You have to give Nexgard Plus and Simparica Trio to your dog by mouth once a month in the shape of a pleasant chewable.

3. Protection against fleas and heartworms

Both Nexgard Plus and Simparica Trio stop Dirofilaria immitis from causing heartworm disease. Both of these medications work equally well to kill adult fleas and help stop and treat flea infestations.

4. Common Tick Protection

Nexgard Plus and Simparica Trio work equally well against these four types of ticks: black-legged tick, American dog tick, brown dog tick, and Lone star tick.

5. Protection against Common Roundworm Types

Nexgard Plus and Simparica Trio are good at treating and controlling roundworm infections in two types of worms: Toxocara canis and Toxascaris leonina.

Differences Between Nexgard Plus and Simparica Trio

There are some key differences between Nexgard Plus and Simparica Trio. The key distinction between them is this:

1. The Making

The active compounds in Nexgard Plus include afoxolaner, moxidectin, and pyrantel.
Salolaner, moxidectin, and pyrantel make up the Simparica Trio.

2. Criteria for Weight

Dogs and pups weighing 4 pounds or more (at least 8 weeks old) are the recommended age for Nexgard Plus, whereas dogs and puppies weighing 2.8 pounds or more (at least 8 weeks old) are the recommended age for Simparica Trio.

3. The Flavor

Nexgard Plus is available in a delicious beef flavor, while Simparica Trio is available in a delicious liver flavor.

4. Protection against Gulf Coast Ticks

The treatment and control of Gulf Coast Ticks, in addition to Black-legged, American dog, brown dog, and Lone star ticks, can be achieved with the use of Simaprica Trio. The four tick species listed above are, however, all effectively killed by Nexgard Plus.

5. Preventing Hookworms

In contrast to Simparica Trio, which is approved for the treatment and management of Ancylostoma caninum and adult Uncinaria stenocephala, Nexgard Plus is effective against three species of hookworms: Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala.

6. Protecting Against Lyme Disease

Simparica Trio is recommended for the prevention of Lyme disease in dogs since it kills black-legged ticks. No evidence of Nexgard Plus’s effectiveness against Lyme disease has been found thus far.

Table of Comparisons Between Nexgard Plus Vs. Simparica Trio

The following table compares the features of the Nexgard Plus and Simparica Trio products in great detail:

Feature	NexGard Plus	Simparica Trio
Minimum Age	8 weeks	8 weeks
Minimum Weight	4 lbs	2.8 lbs
Form	Beef-flavored chew	Liver-flavored chew
Tick Protection	4 species	5 species (incl. Gulf Coast tick)
Flea Protection	✅	✅
Heartworm Prevention	✅	✅
Roundworm Species Covered	2 (T. canis, T. leonina)	2 (T. canis, T. leonina)
Hookworm Species	3 species	2 species
Lyme Disease Prevention	❌	✅
Approved for Pregnant Dogs	Not specified	Vet approval recommended
FDA Approved	✅	✅

Suggestions for Real-World Applications

Go with NexGard Plus if:

• Broad hookworm prevention, including A. braziliense, is necessary for dogs weighing four pounds or more.
• A more recent, tailored approach with good tick coverage (four important species in the US) is what you’re after.
• Because some dogs prefer beef over liver, that’s the flavor you should go for in a chew.

Go with Simparica Trio if:

• The likelihood of tick-borne diseases like Lyme disease is high where you live or where you frequently go to.
• If your dog weighs less than 4 pounds, Trio is a good option, but NexGard Plus isn’t a good fit for him.
• To avoid Lyme illness, you should use a chew that does double duty.

Nexgard Plus and the Simparica Trio: FAQ’s

1. Is it safe to combine Nexgard Plus with Simparica Trio?

No, when it comes to fleas, ticks, heartworm disease, roundworms, and hookworms, both Nexgard Plus and Simparica Trio work just as well. You run the risk of overdosing your dog on parasiticides and causing moderate to severe side effects if you give him both medications at once.

2. Nexgard Plus vs. Simparica Trio: Which is the superior treatment?

Since they are made by separate companies and include different substances, Nexgard Plus and Simparica Trio work in various ways, as we discussed before. But when it comes to fleas, ticks, heartworms, two kinds of roundworms, and hookworms, you can’t go wrong with either of these treatments. There are differences between the lone star tick, Lyme disease, and the Ancylostoma braziliense hookworm species. Ultimately, the best option for your dog will depend on his unique needs.

3. Is Nexgard Plus the same as Simparica Trio?

Yes, but the makers and contents of Nexgard Plus and Simparica Trio couldn’t be more different. Although they work in distinct ways, they both offer protection against a small number of parasites.

4. Nexgard Plus or Simparica Trio: Which one costs more?

The composition, utilities, freight, dealer and reseller share, etc., are some of the factors that impact the price of any antiparasitic therapy.

For personalized advice, always consult your vet based on your dog’s breed, health history, environment, and travel habits.

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